Promethazine hydrochloride and codeine phosphate syrup is indicated for that short term relief of coughs and higher respiratory symptoms related with allergy or the typical cold.
Promethazine with Codeine Oral Answer will not be proposed to be used in Expecting women [see Use in Specific Populations (8.one)]. Extended usage of Promethazine with Codeine Oral Answer all through pregnancy can lead to neonatal opioid withdrawal syndrome, which may be everyday living-threatening if not recognized and addressed, and requires management according to protocols formulated by neonatology industry experts.
All prescription drugs may possibly cause Uncomfortable side effects. Nonetheless, Many individuals don't have any Uncomfortable side effects or have only insignificant Negative effects. Phone your doctor or get professional medical aid if any of those Unwanted effects or every other Unwanted effects bother you or do not go away: Emotion sleepy. Dizziness. Feeling nervous and excitable. Constipation.
Do not forget that this medication has long been prescribed simply because your physician has judged which the gain to you personally is greater than the potential risk of Unwanted side effects. Lots of people applying this medication would not have severe Uncomfortable side effects.
Read through the Medication Manual furnished by your pharmacist Before you begin getting codeine/promethazine and each time you get a refill. When you have any issues, inquire your health care provider or pharmacist.
Discontinuation of the concomitantly utilised cytochrome P450 2D6 inhibitor might result in a minimize in codeine plasma focus and a rise in active metabolite morphine plasma concentration which could improve or lengthen adverse reactions and should result in likely deadly respiratory despair.
Should you be prescribed this medication on an everyday routine and overlook a dose, get it the moment you bear in mind. If it is near the time of the next dose, skip the skipped dose. Acquire your upcoming dose with the standard time. Usually do not double the dose to catch up.
Get emergency health-related support For those who have signs of an allergic reaction: hives; hard respiratory; swelling of one's confront, lips, tongue, or throat.
Promethazine Carcinogenicity scientific studies were executed with promethazine hydrochloride. Two-yr studies in F344/N rats and B6C3F1 mice have been carried out to evaluate the carcinogenic potential of promethazine hydrochloride. No proof of tumorigenicity was observed in male and woman rats at promethazine hydrochloride oral doses as much as 33 mg/kg/day for five times/7 days (somewhere around akin to ten occasions the MRHD over a mg/m two basis).
A healthcare Specialist must be consulted just before taking any drug, changing any diet program or commencing or discontinuing any system of cure.
This product may click here contain inactive ingredients, which can induce allergic reactions or other complications. Check with your pharmacist for more aspects.
Codeine: Narcotic analgesics, which includes codeine, exert their Most important results to the central nervous procedure and gastrointestinal tract. The analgesic outcomes of codeine are as a result of its central action; having said that, the precise websites of action have not been identified, plus the mechanisms concerned seem like rather sophisticated.
Codeine wasn't mutagenic from the in vitro bacterial reverse mutation assay or clastogenic during the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
Go through the Medication Manual furnished by your pharmacist before you start having codeine/promethazine and each time you receive a refill. If you have any issues, request your physician or pharmacist.